My Ph.D. in Bioinformatics was under the supervision of Hans Werner Mewes from the Technical University in Munich and Claudia Petritsch from the University of California, San Francisco. Together we developed one of the first algorithms that deconvolutes a tumor’s sequencing data into clones that coexist in the tumor biopsy. As a postdoctoral fellow, together with Hanlee Ji and Carlo Maley, I quantified intra-tumor heterogeneity in >1000 primary tumors to find that coexistence of multiple clones in the same tumor is indeed the norm. As an Instructor at Stanford in Prof. Ji’s lab, I integrated bulk- and single-cell sequencing approaches to zoom into different perspectives of intra-tumor heterogeneity. The newly gained resolution on coexisting clones and their microenvironment puts us in the yet best position to control and steer subclonal evolution.